Shawn Julian Kile, M.D.

Sutter Neuroscience Institute

Sutter Medical Group, Neuroscience Department

2800 L Street, Suite 500
Sacramento, CA 95816

(916) 454-6850

(916) 454-6800 fax

EDUCATION AND TRAINING:

Cognitive and Behavioral Neurology Subspecialty Training

            07/2006-10/2007

            University of California, Davis

Neurology Residency, Chief Resident

            07/2004-06/2006 (Chief 07/2005-06/2006)

            University of California, Davis

Forensic Psychiatry Fellowship

            07/2003-06/2004

University of California, Davis

Psychiatry Residency, Neuropsychiatry Track

06/1999-06/2003

University of California, Davis

Medical Degree

07/1995-05/1999

University of Texas Medical Branch

Bachelor of Science, Biology Major

08/1991-06/1995

University of Texas at San Antonio

LICENSE AND CERTIFICATION:

American Board of Psychiatry and Neurology, Board Certified

            Diplomate in Neurology                    

            2009-present

            Diplomate in Psychiatry and Forensic Psychiatry                 

            2005-2015

Medical Board of California, Licensed Physician

            09/2000-present

PROFESSIONAL EXPERIENCE:

Sutter Medical Group, Neurologist, subspecializing in Cognitive Neurology

            10/2007-present

            Sutter Neuroscience Memory Clinic

            established 07/2009-present

            Sutter Transition-clinic for Autism and Neurodevelopmental Disorders (S.T.A.N.D.)

            established 05/2009-present

            Sutter Neuroscience Concussion and Traumatic Brain Injury Clinic

            established 09/2012-present

LEADERSHIP EXPERIENCE:

Medical Director of Sutter Neuroscience Institute (Sutter Health Neuroscience Service Line)

            08/2017-present

Regional Chair of Adult Neurology for Sutter Medical Group

            10/2014-present

Physician Care Center Lead for Sutter Medical Group- Neurology Division

            2/2014- 10/2021

Medical Director of Sutter Neuroscience Memory Clinic

            07/2009-present

TEACHING ACTIVITIES:

Professor, UC Davis, Department of Neurology

            01/2008-present (promoted Full Professor 7/2021)

Preceptor, Sutter Medical Center Sacramento, Family Medicine Residency Program, Neurology Rotations

            11/2007-present

Sutter Neurology Case Conference, Organizer/Moderator

            2009-present

Sutter Health Neurodegenerative Case Conference, Presenter

            2020-present

PUBLICATIONS:

Five-year Outcomes after IVIG for Mild Cognitive Impairment due to Alzheimer Disease

BMC Neuroscience, published August 2021; first author

Reduction of amyloid in the brain and retina after treatment with IVIG for Mild Cognitive Impairment

American Journal of Alzheimer's Disease and Other Dementias, published February 2020; first author

Retinal amyloid pathology and proof-of-concept imaging trial in Alzheimer’s disease

Journal of Clinical Investigation, published August 2017

IVIG treatment of Mild Cognitive Impairment due to Alzheimer Disease: a randomized double-blinded exploratory study of the effect on brain atrophy, cognition, and conversion to dementia

Journal of Neurology, Neurosurgery & Psychiatry; published in print February 2017, published ahead of print September 2015; first author

Alzheimer’s Pathology of the Amygdala presenting with Kluver-Bucy Symptoms: An Amygdaloid Variant of Alzheimer’s Disease

Archives of Neurology, published January 2009; first author

Amyloid Clearing Immunotherapy for Alzheimer’s Disease and the Risk of Cerebral Amyloid Angiopathy

Current Research on Alzheimer’s Disease, published 2007; first author

Complex Partial Status Epilepticus in a Patient with Paraneoplastic Limbic Encephalitis associated with Lung Carcinoma

Clinical EEG and Neuroscience, published July 2007; first author

Bithalamic Lesions of Butane Encephalopathy

Pediatric Neurology, published December 2006; first author

Brain Lactate Responses during Visual Stimulation in Fasting and Hyperglycemic Subjects

Psychiatry Research Neuroimaging, published November 2006

Diagnosis and Treatment of Postconcussive Neurobehavioral Symptoms

Continuum, published October 2006; sole author

Neurodevelopmental Pathways to Aggression: A Model to Understand and Target Treatment in Youth

Journal of Neuropsychiatry and Clinical Neurosciences, published August 2006

Pharmacological Intervention for Cognitive Deficits and Aggression in Frontal Lobe Injury

NeuroRehabilitation, published 2006

Neurobehavioral Sequelae of Traumatic Brain Injury

Applied Neurology, published December 2005; first author

Methamphetamine Users in Sustained Abstinence, A Proton Magnetic Resonance Spectroscopy Study

Archives of General Psychiatry, published April 2005

A Dissociation in Attentional Control: Evidence from Methamphetamine Dependence

Biological Psychiatry, published February 2005

Neuroleptic Malignant Syndrome with Dermatological Complications

Journal of Clinical Psychopharmacology, published December 2004

Neuropsychiatric Update: Neuroimaging Schizophrenia

Mental Fitness, published March 2004; sole author

Brain Regions Showing Increased Activation by Threat-Related Words in Panic Disorder

Neuroreport, published March 2003

PRESENTATIONS:

Acute and Chronic Neurologic Complications of COVID-19

            Sutter Health Neuroscience Grand Rounds, January 2022

Brain Health Seminar Series

            Sutter Neuroscience Institute, November 2017-present

Alzheimer’s Disease Research Update (keynote speaker)

Alzheimer's Association Education Forum, April 2017

Updates in Research for Mild Cognitive Impairment and Alzheimer Disease Dementia

            Sutter Neuroscience Annual Symposium, January 2017

IVIG treatment of Mild Cognitive Impairment due to Alzheimer’s Disease

            Octapharma Scientific Symposium, Germany, June 2016

Advances in Neurology

            Sutter Neuroscience Annual Symposium, March 2015

Alzheimer Disease Research Update (keynote speaker)

Alzheimer’s Coalition Conference, September 2014

Dementia

Alzheimer’s Association Annual Conference, May 2013

Advocating for Care- Communicating with your Physician (moderator/speaker, keynote session)

Alzheimer’s Association Annual Conference, April 2012

Alzheimer’s Disease (keynote speaker)

            Alzheimer’s Aid Society Annual Conference, November 2011

The Different Dementias (keynote speaker)

Alzheimer’s Association Annual Conference, March 2010

Dementia with Lewy Bodies

            Parkinson Association Northern California; April 2008.

Alzheimer’s Disease, 100-year Update

            UC Davis Neurology Department Grand Rounds; June 2006.

AWARDS:

2019 University of California Davis Departmental Award

Awarded by the UC Davis School of Medicine in recognition of service and dedication to the department of Neurology.

2015 Excellence in Volunteer Clinical Faculty Award

            Awarded by the UC Davis Neurology Residency Program.

2010 University of California Davis Excellence in Teaching Award

            Awarded by the UC Davis Neurology Residency Program.

2006 American Academy of Neurology Resident Award

Awarded by the Graduate Education Committee of the American Academy of Neurology to residents who have demonstrated a commitment to teaching and education in neurology.

2003 University of California Davis Resident Research Award

Awarded by the UCDMC Department of Psychiatry and Behavioral Sciences for recognition of accomplishments in research; first resident at UCDMC to win this award twice.

2002 Rappeport Fellow

Awarded by the American Academy of Psychiatry and the Law to four residents in the United States for recognition of accomplishments in forensic psychiatry.

2001 University of California Davis Resident Research Award

Awarded by the UCDMC Department of Psychiatry and Behavioral Sciences for recognition of accomplishments in research.   

VOLUNTEER ACTIVITIES:

UC Davis, Volunteer Clinical Faculty

I volunteer monthly to train neurology residents in the clinical assessment and treatment of neurological disorders at the UCD Neurology Residents’ Clinic.

            01/2008-present

RESEARCH EXPERIENCE (in addition to the above publications and abstracts):

New York University/N.I.N.D.S. NeuroCOVID International Registry

            Principal Investigator

            7/2022-present

APOLLO E4 Trial: A Phase 3, Multicenter, Randomized, Double-Blind, Placebo-controlled Study of the Efficacy, Safety and Biomarker Effects of ALZ-801 in Subjects with Early Alzheimer’s Disease and APOE4/4 Genotype

            Principal Investigator

            7/2021-present

NEW Imaging Dementia - Evidence for Amyloid Scanning (IDEAS) study

            Principal Investigator

            08/2020-present

Sutter Health Neurologic Registry for COVID-19

            4/2020-present

GRADUATE Trial: A Phase III, Multicenter, Randomized, Double-blind, Placebo-controlled, Parallel-group, Efficacy, and Safety Study of Gantenerumab in Patients with Early (prodromal to mild) Alzheimer’s Disease

            Principal Investigator

            4/2018-present

The Effect of Intravenous Immunoglobulin on Cerebral and Retinal Amyloid Mild Cognitive Impairment Due to Alzheimer Disease

            Principal Investigator (investigator-initiated study)

            1/2018-7/2018

Anti-Amyloid treatment in Asymptomatic Alzheimer's Disease (A4 Study)

            Principal Investigator

            2017-present

Repeatability and Reproducibility of Autofluorescence Measurements by NeuroVision in Normal and Diseased Subjects

            Principal Investigator; Sutter Neuroscience Institute in collaboration with Neurovision

            3/2017-2018

A Long-term Extension Study of the Safety and Tolerability of RVT-101 in subjects with dementia with Lewy bodies (DLB)

            Principal Investigator

            08/2017-03/2018

A Phase 2b, Double-Blind, Randomized, Placebo-Controlled Study of RVT-101 in Subjects with Lewy Bodies

            Principal Investigator

            8/2016-8/2017

Effect of LY3202626 on Alzheimer’s Disease Progression as Measured by Cerebral 18F-AV-1451 Tau-PET in Mild Alzheimer’s Disease Dementia

            Principal Investigator

            2017-present

Imaging Dementia - Evidence for Amyloid Scanning (IDEAS study)

            Principal Investigator

            2/2016-12/2017

The Synkinetic Sign: a single-blinded investigation of a novel neurological sign for the early detection of Lewy body/Parkinson disease

            Principal Investigator (investigator-initiated study)

            11/2014-present

An Open Label, Multicenter Study, Evaluating the Safety and Imaging Characteristics of F18-AV-1451 in Cognitively Healthy Volunteers, Mild Cognitive Impairment, and Alzheimer’s Disease

            Investigator

            08/2014-01/2018

A Parallel-Group Randomized, Double-Blind, Long Term Safety and Efficacy Trial of MK-8931 in Subjects with Amnestic Mild Cognitive Impairment Due to Alzheimer Disease

            Principal Investigator

            2013-present

A Randomized, Double-blinded, Placebo-controlled Trial of Intravenous Immunoglobulin (NewGam 10%) for Mild Cognitive Impairment due to Alzheimer Disease

            Principal Investigator (investigator-initiated study)

            2011-present

A Phase III, Randomized, Placebo Controlled, Parallel-Group, Double Blind Clinical Trial of Study Efficacy and Safety Trial of MK-8931 in Subjects with Amnestic Mild Cognitive Impairment Due to Alzheimer’s Disease

            Principal Investigator

            03/2014-7/2018

A Randomized, Placebo Controlled, Parallel-Group, Double Blind Efficacy and Safety Trial of MK-8931 in Subjects with Mild to Moderate Alzheimer Disease

            Principal Investigator

            05/2013-8/2017

A Randomized, Placebo-controlled, Blinded, Crossover, Single-Center Study of the Effects of Nuedexta in the Treatment of Neurobehavioral Symptoms of Adults with Autism Spectrum Disorder

            Co-Investigator

            2012-2016

A Pilot Study to detect A-Beta Plaques utilizing Retinal Imaging System in Alzheimer Disease

            Principal Investigator; Sutter Neuroscience Institute in collaboration with Neurovision

            2012-2013

A Phase III, Multicenter, Randomized, Double-blind, Placebo-controlled, Parallel-group, Efficacy and Safety Trial of Bapineuzumab in subjects with Mild to Moderate Alzheimer’s Disease (APOE4 Carriers and Non-Carriers)

            Sub-investigator         

            2008-2012

The Ginkgo Evaluation of Memory (GEM) study: a randomized trial of Ginkgo biloba extract in prevention of dementia

Research neurologic examiner; University of California Davis Alzheimer’s Disease Center

            2006-2007

Dementia Cohort II Study: Longitudinal Study of Mild Cognitive Impairment

Research neurologic examiner; University of California Davis Alzheimer’s Disease Center

2006-2007

Alzheimer's Disease Neuroimaging Initiative

Research neurologic examiner; University of California Davis Alzheimer’s Disease Center

            2006-2007

Double-blind, Randomized, Placebo-Controlled, Clinical Trial of Venlafaxine-ER and Sertraline in the Treatment of PTSD

Sub-investigator; University of California Davis Medical Center

            2001-2002

INTERNATIONAL RESEARCH PEER-REVIEW PANEL:

 Alzheimer's Association International Research Grant Program, Reviewer

            2011-present

NATIONAL AND REGIONAL COMMITTEES:

Sutter Health Education and Research Committee

            11/2016-present

Sutter Neuroscience Institute - Neuroscience Clinical Innovation and Research Committee

            08/2016-present (Committee Director)

Sutter Neuroscience Research Consortium Executive Committee

            Sac-Sierra and Central Valley Regional Lead

            9/2014-present

Sutter Medical Group, Regional Quality Management Committee

            1/2014-8/2022

Sutter Institute for Medical Research Committee

            2012-present

Forensic Neuropsychiatry Committee

            American Academy of Psychiatry and the Law

2002-2010

ORGANIZATION MEMBERSHIPS:

American Academy of Neurology

            Behavioral Neurology Section Member

American Medical Association